Mesenchymal stem cells derived from inflamed dental pulpal and gingival tissue: a potential application for bone formation
Identifieur interne : 000161 ( Main/Exploration ); précédent : 000160; suivant : 000162Mesenchymal stem cells derived from inflamed dental pulpal and gingival tissue: a potential application for bone formation
Auteurs : Laura Tomasello [Italie] ; Rodolfo Mauceri [Italie] ; Antonina Coppola [Italie] ; Maria Pitrone [Italie] ; Giuseppe Pizzo [Italie] ; Giuseppina Campisi [Italie] ; Giuseppe Pizzolanti [Italie] ; Carla Giordano [Italie]Source :
- Stem Cell Research & Therapy [ 1757-6512 ] ; 2017.
Abstract
Chronic periodontal disease is an infectious disease consisting of prolonged inflammation of the supporting tooth tissue and resulting in bone loss. Guided bone regeneration procedures have become common and safe treatments in dentistry, and in this context dental stem cells would represent the ideal solution as autologous cells. In this study, we verified the ability of dental pulp mesenchymal stem cells (DPSCs) and gingival mesenchymal stem cells (GMSCs) harvested from periodontally affected teeth to produce new mineralized bone tissue in vitro, and compared this to cells from healthy teeth.
To characterize DPSCs and GMSCs, we assessed colony-forming assay, immunophenotyping, mesenchymal/stem cell phenotyping, stem gene profiling by means of flow cytometry, and quantitative polymerase chain reaction (qPCR). The effects of proinflammatory cytokines on mesenchymal stem cell (MSC) proliferation and differentiation potential were investigated. We also observed participation of several heat shock proteins (HSPs) and actin-depolymerizing factors (ADFs) during osteogenic differentiation.
DPSCs and GMSCs were successfully isolated both from periodontally affected dental tissue and controls. Periodontally affected dental MSCs proliferated faster, and the inflamed environment did not affect MSC marker expressions. The calcium deposition was higher in periodontally affected MSCs than in the control group.
Proinflammatory cytokines activate a cytoskeleton remodeling, interacting with HSPs including HSP90 and HSPA9, thioredoxin-1, and ADFs such as as profilin-1, cofilin-1, and vinculin that probably mediate the increased acquisition in the inflamed environment.
Our findings provide evidence that periodontally affected dental tissue (both pulp and gingiva) can be used as a source of MSCs with intact stem cell properties. Moreover, we demonstrated that the osteogenic capability of DPSCs and GMSCs in the test group was not only preserved but increased by the overexpression of several proinflammatory cytokine-dependent chaperones and stress response proteins.
The online version of this article (doi:10.1186/s13287-017-0633-z) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13287-017-0633-z
PubMed: 28764802
PubMed Central: 5540218
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000D80
- to stream Pmc, to step Curation: 000D80
- to stream Pmc, to step Checkpoint: 000147
- to stream Ncbi, to step Merge: 007126
- to stream Ncbi, to step Curation: 007126
- to stream Ncbi, to step Checkpoint: 007126
- to stream Main, to step Merge: 000161
- to stream Main, to step Curation: 000161
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mesenchymal stem cells derived from inflamed dental pulpal and gingival tissue: a potential application for bone formation</title><author><name sortKey="Tomasello, Laura" sort="Tomasello, Laura" uniqKey="Tomasello L" first="Laura" last="Tomasello">Laura Tomasello</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Laboratory of Regenerative Medicine “Aldo Galluzzo”, Department of Endocrinology, Diabetology and Metabolism,</institution><institution>University of Palermo,</institution></institution-wrap>Piazza Delle Cliniche 2, 90127 Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Piazza Delle Cliniche 2, 90127 Palermo</wicri:regionArea><wicri:noRegion>90127 Palermo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Advanced Technologies Network Center,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Mauceri, Rodolfo" sort="Mauceri, Rodolfo" uniqKey="Mauceri R" first="Rodolfo" last="Mauceri">Rodolfo Mauceri</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Department of Surgical, Oncological and Oral Sciences,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Coppola, Antonina" sort="Coppola, Antonina" uniqKey="Coppola A" first="Antonina" last="Coppola">Antonina Coppola</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Laboratory of Regenerative Medicine “Aldo Galluzzo”, Department of Endocrinology, Diabetology and Metabolism,</institution><institution>University of Palermo,</institution></institution-wrap>Piazza Delle Cliniche 2, 90127 Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Piazza Delle Cliniche 2, 90127 Palermo</wicri:regionArea><wicri:noRegion>90127 Palermo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Advanced Technologies Network Center,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Pitrone, Maria" sort="Pitrone, Maria" uniqKey="Pitrone M" first="Maria" last="Pitrone">Maria Pitrone</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Laboratory of Regenerative Medicine “Aldo Galluzzo”, Department of Endocrinology, Diabetology and Metabolism,</institution><institution>University of Palermo,</institution></institution-wrap>Piazza Delle Cliniche 2, 90127 Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Piazza Delle Cliniche 2, 90127 Palermo</wicri:regionArea><wicri:noRegion>90127 Palermo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Advanced Technologies Network Center,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Pizzo, Giuseppe" sort="Pizzo, Giuseppe" uniqKey="Pizzo G" first="Giuseppe" last="Pizzo">Giuseppe Pizzo</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Department of Surgical, Oncological and Oral Sciences,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Campisi, Giuseppina" sort="Campisi, Giuseppina" uniqKey="Campisi G" first="Giuseppina" last="Campisi">Giuseppina Campisi</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Department of Surgical, Oncological and Oral Sciences,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Pizzolanti, Giuseppe" sort="Pizzolanti, Giuseppe" uniqKey="Pizzolanti G" first="Giuseppe" last="Pizzolanti">Giuseppe Pizzolanti</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Laboratory of Regenerative Medicine “Aldo Galluzzo”, Department of Endocrinology, Diabetology and Metabolism,</institution><institution>University of Palermo,</institution></institution-wrap>Piazza Delle Cliniche 2, 90127 Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Piazza Delle Cliniche 2, 90127 Palermo</wicri:regionArea><wicri:noRegion>90127 Palermo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Advanced Technologies Network Center,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Giordano, Carla" sort="Giordano, Carla" uniqKey="Giordano C" first="Carla" last="Giordano">Carla Giordano</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Laboratory of Regenerative Medicine “Aldo Galluzzo”, Department of Endocrinology, Diabetology and Metabolism,</institution><institution>University of Palermo,</institution></institution-wrap>Piazza Delle Cliniche 2, 90127 Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Piazza Delle Cliniche 2, 90127 Palermo</wicri:regionArea><wicri:noRegion>90127 Palermo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Advanced Technologies Network Center,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28764802</idno><idno type="pmc">5540218</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540218</idno><idno type="RBID">PMC:5540218</idno><idno type="doi">10.1186/s13287-017-0633-z</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000D80</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D80</idno><idno type="wicri:Area/Pmc/Curation">000D80</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D80</idno><idno type="wicri:Area/Pmc/Checkpoint">000147</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000147</idno><idno type="wicri:Area/Ncbi/Merge">007126</idno><idno type="wicri:Area/Ncbi/Curation">007126</idno><idno type="wicri:Area/Ncbi/Checkpoint">007126</idno><idno type="wicri:Area/Main/Merge">000161</idno><idno type="wicri:Area/Main/Curation">000161</idno><idno type="wicri:Area/Main/Exploration">000161</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mesenchymal stem cells derived from inflamed dental pulpal and gingival tissue: a potential application for bone formation</title><author><name sortKey="Tomasello, Laura" sort="Tomasello, Laura" uniqKey="Tomasello L" first="Laura" last="Tomasello">Laura Tomasello</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Laboratory of Regenerative Medicine “Aldo Galluzzo”, Department of Endocrinology, Diabetology and Metabolism,</institution><institution>University of Palermo,</institution></institution-wrap>Piazza Delle Cliniche 2, 90127 Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Piazza Delle Cliniche 2, 90127 Palermo</wicri:regionArea><wicri:noRegion>90127 Palermo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Advanced Technologies Network Center,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Mauceri, Rodolfo" sort="Mauceri, Rodolfo" uniqKey="Mauceri R" first="Rodolfo" last="Mauceri">Rodolfo Mauceri</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Department of Surgical, Oncological and Oral Sciences,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Coppola, Antonina" sort="Coppola, Antonina" uniqKey="Coppola A" first="Antonina" last="Coppola">Antonina Coppola</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Laboratory of Regenerative Medicine “Aldo Galluzzo”, Department of Endocrinology, Diabetology and Metabolism,</institution><institution>University of Palermo,</institution></institution-wrap>Piazza Delle Cliniche 2, 90127 Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Piazza Delle Cliniche 2, 90127 Palermo</wicri:regionArea><wicri:noRegion>90127 Palermo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Advanced Technologies Network Center,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Pitrone, Maria" sort="Pitrone, Maria" uniqKey="Pitrone M" first="Maria" last="Pitrone">Maria Pitrone</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Laboratory of Regenerative Medicine “Aldo Galluzzo”, Department of Endocrinology, Diabetology and Metabolism,</institution><institution>University of Palermo,</institution></institution-wrap>Piazza Delle Cliniche 2, 90127 Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Piazza Delle Cliniche 2, 90127 Palermo</wicri:regionArea><wicri:noRegion>90127 Palermo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Advanced Technologies Network Center,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Pizzo, Giuseppe" sort="Pizzo, Giuseppe" uniqKey="Pizzo G" first="Giuseppe" last="Pizzo">Giuseppe Pizzo</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Department of Surgical, Oncological and Oral Sciences,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Campisi, Giuseppina" sort="Campisi, Giuseppina" uniqKey="Campisi G" first="Giuseppina" last="Campisi">Giuseppina Campisi</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Department of Surgical, Oncological and Oral Sciences,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Pizzolanti, Giuseppe" sort="Pizzolanti, Giuseppe" uniqKey="Pizzolanti G" first="Giuseppe" last="Pizzolanti">Giuseppe Pizzolanti</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Laboratory of Regenerative Medicine “Aldo Galluzzo”, Department of Endocrinology, Diabetology and Metabolism,</institution><institution>University of Palermo,</institution></institution-wrap>Piazza Delle Cliniche 2, 90127 Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Piazza Delle Cliniche 2, 90127 Palermo</wicri:regionArea><wicri:noRegion>90127 Palermo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Advanced Technologies Network Center,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author><author><name sortKey="Giordano, Carla" sort="Giordano, Carla" uniqKey="Giordano C" first="Carla" last="Giordano">Carla Giordano</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Laboratory of Regenerative Medicine “Aldo Galluzzo”, Department of Endocrinology, Diabetology and Metabolism,</institution><institution>University of Palermo,</institution></institution-wrap>Piazza Delle Cliniche 2, 90127 Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Piazza Delle Cliniche 2, 90127 Palermo</wicri:regionArea><wicri:noRegion>90127 Palermo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution>Advanced Technologies Network Center,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Palermo</wicri:regionArea></affiliation></author></analytic><series><title level="j">Stem Cell Research & Therapy</title><idno type="eISSN">1757-6512</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Chronic periodontal disease is an infectious disease consisting of prolonged inflammation of the supporting tooth tissue and resulting in bone loss. Guided bone regeneration procedures have become common and safe treatments in dentistry, and in this context dental stem cells would represent the ideal solution as autologous cells. In this study, we verified the ability of dental pulp mesenchymal stem cells (DPSCs) and gingival mesenchymal stem cells (GMSCs) harvested from periodontally affected teeth to produce new mineralized bone tissue in vitro, and compared this to cells from healthy teeth.</p></sec><sec><title>Methods</title><p id="Par2">To characterize DPSCs and GMSCs, we assessed colony-forming assay, immunophenotyping, mesenchymal/stem cell phenotyping, stem gene profiling by means of flow cytometry, and quantitative polymerase chain reaction (qPCR). The effects of proinflammatory cytokines on mesenchymal stem cell (MSC) proliferation and differentiation potential were investigated. We also observed participation of several heat shock proteins (HSPs) and actin-depolymerizing factors (ADFs) during osteogenic differentiation.</p></sec><sec><title>Results</title><p id="Par3">DPSCs and GMSCs were successfully isolated both from periodontally affected dental tissue and controls. Periodontally affected dental MSCs proliferated faster, and the inflamed environment did not affect MSC marker expressions. The calcium deposition was higher in periodontally affected MSCs than in the control group.</p><p id="Par4">Proinflammatory cytokines activate a cytoskeleton remodeling, interacting with HSPs including HSP90 and HSPA9, thioredoxin-1, and ADFs such as as profilin-1, cofilin-1, and vinculin that probably mediate the increased acquisition in the inflamed environment.</p></sec><sec><title>Conclusions</title><p id="Par5">Our findings provide evidence that periodontally affected dental tissue (both pulp and gingiva) can be used as a source of MSCs with intact stem cell properties. Moreover, we demonstrated that the osteogenic capability of DPSCs and GMSCs in the test group was not only preserved but increased by the overexpression of several proinflammatory cytokine-dependent chaperones and stress response proteins.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13287-017-0633-z) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Highfield, J" uniqKey="Highfield J">J Highfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burt, B" uniqKey="Burt B">B Burt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tomasi, C" uniqKey="Tomasi C">C Tomasi</name></author><author><name sortKey="Wennstrom, Jl" uniqKey="Wennstrom J">JL Wennström</name></author><author><name sortKey="Berglundh, T" uniqKey="Berglundh T">T Berglundh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pietrokovski, J" uniqKey="Pietrokovski J">J Pietrokovski</name></author><author><name sortKey="Starinsky, R" uniqKey="Starinsky R">R Starinsky</name></author><author><name sortKey="Arensburg, B" uniqKey="Arensburg B">B Arensburg</name></author><author><name sortKey="Kaffe, I" uniqKey="Kaffe I">I Kaffe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Misawa, M" uniqKey="Misawa M">M Misawa</name></author><author><name sortKey="Lindhe, J" uniqKey="Lindhe J">J Lindhe</name></author><author><name sortKey="Araujo, Mg" uniqKey="Araujo M">MG Araújo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esposito, M" uniqKey="Esposito M">M Esposito</name></author><author><name sortKey="Grusovin, Mg" uniqKey="Grusovin M">MG Grusovin</name></author><author><name sortKey="Felice, P" uniqKey="Felice P">P Felice</name></author><author><name sortKey="Karatzopoulos, G" uniqKey="Karatzopoulos G">G Karatzopoulos</name></author><author><name sortKey="Worthington, Hv" uniqKey="Worthington H">HV Worthington</name></author><author><name sortKey="Coulthard, P" uniqKey="Coulthard P">P Coulthard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calori, Gm" uniqKey="Calori G">GM Calori</name></author><author><name sortKey="Mazza, E" uniqKey="Mazza E">E Mazza</name></author><author><name sortKey="Colombo, M" uniqKey="Colombo M">M Colombo</name></author><author><name sortKey="Ripamonti, C" uniqKey="Ripamonti C">C Ripamonti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zizzari, Vl" uniqKey="Zizzari V">VL Zizzari</name></author><author><name sortKey="Zara, S" uniqKey="Zara S">S Zara</name></author><author><name sortKey="Tete, G" uniqKey="Tete G">G Tetè</name></author><author><name sortKey="Vinci, R" uniqKey="Vinci R">R Vinci</name></author><author><name sortKey="Gherlone, E" uniqKey="Gherlone E">E Gherlone</name></author><author><name sortKey="Cataldi, A" uniqKey="Cataldi A">A Cataldi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caplan, Ai" uniqKey="Caplan A">AI Caplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salgado, Aj" uniqKey="Salgado A">AJ Salgado</name></author><author><name sortKey="Oliveira, Jm" uniqKey="Oliveira J">JM Oliveira</name></author><author><name sortKey="Martins, A" uniqKey="Martins A">A Martins</name></author><author><name sortKey="Teixeira, Fg" uniqKey="Teixeira F">FG Teixeira</name></author><author><name sortKey="Silva, Na" uniqKey="Silva N">NA Silva</name></author><author><name sortKey="Neves, Nm" uniqKey="Neves N">NM Neves</name></author><author><name sortKey="Sousa, N" uniqKey="Sousa N">N Sousa</name></author><author><name sortKey="Reis, Rl" uniqKey="Reis R">RL Reis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Quino, R" uniqKey="D Quino R">R D’Aquino</name></author><author><name sortKey="De Rosa, A" uniqKey="De Rosa A">A De Rosa</name></author><author><name sortKey="Laino, G" uniqKey="Laino G">G Laino</name></author><author><name sortKey="Caruso, F" uniqKey="Caruso F">F Caruso</name></author><author><name sortKey="Guida, L" uniqKey="Guida L">L Guida</name></author><author><name sortKey="Rullo, R" uniqKey="Rullo R">R Rullo</name></author><author><name sortKey="Checchi, V" uniqKey="Checchi V">V Checchi</name></author><author><name sortKey="Laino, L" uniqKey="Laino L">L Laino</name></author><author><name sortKey="Tirino, V" uniqKey="Tirino V">V Tirino</name></author><author><name sortKey="Papaccio, G" uniqKey="Papaccio G">G Papaccio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name></author><author><name sortKey="Jiang, B" uniqKey="Jiang B">B Jiang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Xu, Gt" uniqKey="Xu G">GT Xu</name></author><author><name sortKey="Liang, A" uniqKey="Liang A">A Liang</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nuti, N" uniqKey="Nuti N">N Nuti</name></author><author><name sortKey="Corallo, C" uniqKey="Corallo C">C Corallo</name></author><author><name sortKey="Chan, Bm" uniqKey="Chan B">BM Chan</name></author><author><name sortKey="Ferrari, M" uniqKey="Ferrari M">M Ferrari</name></author><author><name sortKey="Gerami Naini, B" uniqKey="Gerami Naini B">B Gerami-Naini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walker, Mr" uniqKey="Walker M">MR Walker</name></author><author><name sortKey="Patel, Kk" uniqKey="Patel K">KK Patel</name></author><author><name sortKey="Stappenbeck, Ts" uniqKey="Stappenbeck T">TS Stappenbeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, Pa" uniqKey="Hall P">PA Hall</name></author><author><name sortKey="Watt, Fm" uniqKey="Watt F">FM Watt</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, H" uniqKey="Zhao H">H Zhao</name></author><author><name sortKey="Chai, Y" uniqKey="Chai Y">Y Chai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gronthos, S" uniqKey="Gronthos S">S Gronthos</name></author><author><name sortKey="Mankani, M" uniqKey="Mankani M">M Mankani</name></author><author><name sortKey="Brahim, J" uniqKey="Brahim J">J Brahim</name></author><author><name sortKey="Robey, Pg" uniqKey="Robey P">PG Robey</name></author><author><name sortKey="Shi, S" uniqKey="Shi S">S Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miura, M" uniqKey="Miura M">M Miura</name></author><author><name sortKey="Gronthos, S" uniqKey="Gronthos S">S Gronthos</name></author><author><name sortKey="Zhao, M" uniqKey="Zhao M">M Zhao</name></author><author><name sortKey="Lu, B" uniqKey="Lu B">B Lu</name></author><author><name sortKey="Fisher, Lw" uniqKey="Fisher L">LW Fisher</name></author><author><name sortKey="Robey, Pg" uniqKey="Robey P">PG Robey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo, Bm" uniqKey="Seo B">BM Seo</name></author><author><name sortKey="Miura, M" uniqKey="Miura M">M Miura</name></author><author><name sortKey="Gronthos, S" uniqKey="Gronthos S">S Gronthos</name></author><author><name sortKey="Bartold, Pm" uniqKey="Bartold P">PM Bartold</name></author><author><name sortKey="Batouli, S" uniqKey="Batouli S">S Batouli</name></author><author><name sortKey="Brahim, J" uniqKey="Brahim J">J Brahim</name></author><author><name sortKey="Young, M" uniqKey="Young M">M Young</name></author><author><name sortKey="Robey, Pg" uniqKey="Robey P">PG Robey</name></author><author><name sortKey="Wang, Cy" uniqKey="Wang C">CY Wang</name></author><author><name sortKey="Shi, S" uniqKey="Shi S">S Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sonoyama, W" uniqKey="Sonoyama W">W Sonoyama</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Yamaza, T" uniqKey="Yamaza T">T Yamaza</name></author><author><name sortKey="Tuan, Rs" uniqKey="Tuan R">RS Tuan</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Shi, S" uniqKey="Shi S">S Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Shi, S" uniqKey="Shi S">S Shi</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Uyanne, J" uniqKey="Uyanne J">J Uyanne</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author><author><name sortKey="Shi, S" uniqKey="Shi S">S Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Ah" uniqKey="Huang A">AH Huang</name></author><author><name sortKey="Chen, Yk" uniqKey="Chen Y">YK Chen</name></author><author><name sortKey="Chan, Aw" uniqKey="Chan A">AW Chan</name></author><author><name sortKey="Shieh, Ty" uniqKey="Shieh T">TY Shieh</name></author><author><name sortKey="Lin, Lm" uniqKey="Lin L">LM Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rajendran, R" uniqKey="Rajendran R">R Rajendran</name></author><author><name sortKey="Gopal, S" uniqKey="Gopal S">S Gopal</name></author><author><name sortKey="Masood, H" uniqKey="Masood H">H Masood</name></author><author><name sortKey="Vivek, P" uniqKey="Vivek P">P Vivek</name></author><author><name sortKey="Deb, K" uniqKey="Deb K">K Deb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Pan, J" uniqKey="Pan J">J Pan</name></author><author><name sortKey="Wright, Jt" uniqKey="Wright J">JT Wright</name></author><author><name sortKey="Bencharit, S" uniqKey="Bencharit S">S Bencharit</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Everett, Et" uniqKey="Everett E">ET Everett</name></author><author><name sortKey="Teixeira, Fb" uniqKey="Teixeira F">FB Teixeira</name></author><author><name sortKey="Preisser, Js" uniqKey="Preisser J">JS Preisser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, Hh" uniqKey="Sun H">HH Sun</name></author><author><name sortKey="Chen, B" uniqKey="Chen B">B Chen</name></author><author><name sortKey="Zhu, Ql" uniqKey="Zhu Q">QL Zhu</name></author><author><name sortKey="Kong, H" uniqKey="Kong H">H Kong</name></author><author><name sortKey="Li, Qh" uniqKey="Li Q">QH Li</name></author><author><name sortKey="Gao, Ln" uniqKey="Gao L">LN Gao</name></author><author><name sortKey="Xiao, M" uniqKey="Xiao M">M Xiao</name></author><author><name sortKey="Chen, Fm" uniqKey="Chen F">FM Chen</name></author><author><name sortKey="Yu, Q" uniqKey="Yu Q">Q Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alge, Dl" uniqKey="Alge D">DL Alge</name></author><author><name sortKey="Zhou, D" uniqKey="Zhou D">D Zhou</name></author><author><name sortKey="Adams, Ll" uniqKey="Adams L">LL Adams</name></author><author><name sortKey="Wyss, Bk" uniqKey="Wyss B">BK Wyss</name></author><author><name sortKey="Shadday, Md" uniqKey="Shadday M">MD Shadday</name></author><author><name sortKey="Woods, Ej" uniqKey="Woods E">EJ Woods</name></author><author><name sortKey="Gabriel Chu, Tm" uniqKey="Gabriel Chu T">TM Gabriel Chu</name></author><author><name sortKey="Goebel, Ws" uniqKey="Goebel W">WS Goebel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawashima, N" uniqKey="Kawashima N">N Kawashima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Deng, Z" uniqKey="Deng Z">Z Deng</name></author><author><name sortKey="Tang, L" uniqKey="Tang L">L Tang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Jin, Y" uniqKey="Jin Y">Y Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, N" uniqKey="Li N">N Li</name></author><author><name sortKey="Liu, N" uniqKey="Liu N">N Liu</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Tang, L" uniqKey="Tang L">L Tang</name></author><author><name sortKey="Ding, B" uniqKey="Ding B">B Ding</name></author><author><name sortKey="Duan, Y" uniqKey="Duan Y">Y Duan</name></author><author><name sortKey="Jin, Y" uniqKey="Jin Y">Y Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author><author><name sortKey="Gao, Ln" uniqKey="Gao L">LN Gao</name></author><author><name sortKey="An, Y" uniqKey="An Y">Y An</name></author><author><name sortKey="Hu, Ch" uniqKey="Hu C">CH Hu</name></author><author><name sortKey="Jin, F" uniqKey="Jin F">F Jin</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Jin, Y" uniqKey="Jin Y">Y Jin</name></author><author><name sortKey="Chen, Fm" uniqKey="Chen F">FM Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hess, K" uniqKey="Hess K">K Hess</name></author><author><name sortKey="Ushmorov, A" uniqKey="Ushmorov A">A Ushmorov</name></author><author><name sortKey="Fiedler, J" uniqKey="Fiedler J">J Fiedler</name></author><author><name sortKey="Brenner, Re" uniqKey="Brenner R">RE Brenner</name></author><author><name sortKey="Wirth, T" uniqKey="Wirth T">T Wirth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hronik Tupaj, M" uniqKey="Hronik Tupaj M">M Hronik-Tupaj</name></author><author><name sortKey="Rice, Wl" uniqKey="Rice W">WL Rice</name></author><author><name sortKey="Cronin Golomb, M" uniqKey="Cronin Golomb M">M Cronin-Golomb</name></author><author><name sortKey="Kaplan, Dl" uniqKey="Kaplan D">DL Kaplan</name></author><author><name sortKey="Georgakoudi, I" uniqKey="Georgakoudi I">I Georgakoudi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patil, S" uniqKey="Patil S">S Patil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen" uniqKey="Chen">Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name></author><author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorska, R" uniqKey="Gorska R">R Gorska</name></author><author><name sortKey="Gregorek, H" uniqKey="Gregorek H">H Gregorek</name></author><author><name sortKey="Kowalski, J" uniqKey="Kowalski J">J Kowalski</name></author><author><name sortKey="Laskus Perendyk, A" uniqKey="Laskus Perendyk A">A Laskus-Perendyk</name></author><author><name sortKey="Syczewska, M" uniqKey="Syczewska M">M Syczewska</name></author><author><name sortKey="Madalinski, K" uniqKey="Madalinski K">K Madalinski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Pang, X" uniqKey="Pang X">X Pang</name></author><author><name sortKey="Fan, M" uniqKey="Fan M">M Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palmqvist, P" uniqKey="Palmqvist P">P Palmqvist</name></author><author><name sortKey="Lundberg, P" uniqKey="Lundberg P">P Lundberg</name></author><author><name sortKey="Lundgren, I" uniqKey="Lundgren I">I Lundgren</name></author><author><name sortKey="H Nstrom, L" uniqKey="H Nstrom L">L Hänström</name></author><author><name sortKey="Lerner, Uh" uniqKey="Lerner U">UH Lerner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, X" uniqKey="Feng X">X Feng</name></author><author><name sortKey="Feng, G" uniqKey="Feng G">G Feng</name></author><author><name sortKey="Xing, J" uniqKey="Xing J">J Xing</name></author><author><name sortKey="Shen, B" uniqKey="Shen B">B Shen</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author><author><name sortKey="Jiang, J" uniqKey="Jiang J">J Jiang</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author><author><name sortKey="Tao, T" uniqKey="Tao T">T Tao</name></author><author><name sortKey="Gu, Z" uniqKey="Gu Z">Z Gu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carrero, R" uniqKey="Carrero R">R Carrero</name></author><author><name sortKey="Cerrada, I" uniqKey="Cerrada I">I Cerrada</name></author><author><name sortKey="Lled, E" uniqKey="Lled E">E Lledó</name></author><author><name sortKey="Dopazo, J" uniqKey="Dopazo J">J Dopazo</name></author><author><name sortKey="Garcia Garcia, F" uniqKey="Garcia Garcia F">F García-García</name></author><author><name sortKey="Rubio, Mp" uniqKey="Rubio M">MP Rubio</name></author><author><name sortKey="Trigueros, C" uniqKey="Trigueros C">C Trigueros</name></author><author><name sortKey="Dorronsoro, A" uniqKey="Dorronsoro A">A Dorronsoro</name></author><author><name sortKey="Ruiz Sauri, A" uniqKey="Ruiz Sauri A">A Ruiz-Sauri</name></author><author><name sortKey="Montero, Ja" uniqKey="Montero J">JA Montero</name></author><author><name sortKey="Sepulveda, P" uniqKey="Sepulveda P">P Sepúlveda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cuerquis, J" uniqKey="Cuerquis J">J Cuerquis</name></author><author><name sortKey="Romieu Mourez, R" uniqKey="Romieu Mourez R">R Romieu-Mourez</name></author><author><name sortKey="Francois, M" uniqKey="Francois M">M François</name></author><author><name sortKey="Routy, Jp" uniqKey="Routy J">JP Routy</name></author><author><name sortKey="Young, Yk" uniqKey="Young Y">YK Young</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Eliopoulos, N" uniqKey="Eliopoulos N">N Eliopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fu, X" uniqKey="Fu X">X Fu</name></author><author><name sortKey="Xiao, J" uniqKey="Xiao J">J Xiao</name></author><author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Yin, J" uniqKey="Yin J">J Yin</name></author><author><name sortKey="Sun, K" uniqKey="Sun K">K Sun</name></author><author><name sortKey="Sun, H" uniqKey="Sun H">H Sun</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author><author><name sortKey="Zhang, Bt" uniqKey="Zhang B">BT Zhang</name></author><author><name sortKey="Sheng, C" uniqKey="Sheng C">C Sheng</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Ping, H" uniqKey="Ping H">H Ping</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ennis, Wj" uniqKey="Ennis W">WJ Ennis</name></author><author><name sortKey="Sui, A" uniqKey="Sui A">A Sui</name></author><author><name sortKey="Bartholomew, A" uniqKey="Bartholomew A">A Bartholomew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcbeath, R" uniqKey="Mcbeath R">R McBeath</name></author><author><name sortKey="Pirone, Dm" uniqKey="Pirone D">DM Pirone</name></author><author><name sortKey="Nelson, Cm" uniqKey="Nelson C">CM Nelson</name></author><author><name sortKey="Bhadriraju, K" uniqKey="Bhadriraju K">K Bhadriraju</name></author><author><name sortKey="Chen, Cs" uniqKey="Chen C">CS Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, G" uniqKey="Feng G">G Feng</name></author><author><name sortKey="Zheng, K" uniqKey="Zheng K">K Zheng</name></author><author><name sortKey="Song, D" uniqKey="Song D">D Song</name></author><author><name sortKey="Xu, K" uniqKey="Xu K">K Xu</name></author><author><name sortKey="Huang, D" uniqKey="Huang D">D Huang</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Cao, P" uniqKey="Cao P">P Cao</name></author><author><name sortKey="Shen, S" uniqKey="Shen S">S Shen</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Feng, X" uniqKey="Feng X">X Feng</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yourek, G" uniqKey="Yourek G">G Yourek</name></author><author><name sortKey="Hussain, Ma" uniqKey="Hussain M">MA Hussain</name></author><author><name sortKey="Mao, Jj" uniqKey="Mao J">JJ Mao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Treiser, Md" uniqKey="Treiser M">MD Treiser</name></author><author><name sortKey="Yang, Eh" uniqKey="Yang E">EH Yang</name></author><author><name sortKey="Gordonov, S" uniqKey="Gordonov S">S Gordonov</name></author><author><name sortKey="Cohen, Dm" uniqKey="Cohen D">DM Cohen</name></author><author><name sortKey="Androulakis, Ip" uniqKey="Androulakis I">IP Androulakis</name></author><author><name sortKey="Kohn, J" uniqKey="Kohn J">J Kohn</name></author><author><name sortKey="Chen, Cs" uniqKey="Chen C">CS Chen</name></author><author><name sortKey="Moghe, Pv" uniqKey="Moghe P">PV Moghe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author><author><name sortKey="Shanmin, F" uniqKey="Shanmin F">F Shanmin</name></author><author><name sortKey="Zeng, Z" uniqKey="Zeng Z">Z Zeng</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Niu, Q" uniqKey="Niu Q">Q Niu</name></author><author><name sortKey="Jing, D" uniqKey="Jing D">D Jing</name></author><author><name sortKey="Feng, X" uniqKey="Feng X">X Feng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sen, B" uniqKey="Sen B">B Sen</name></author><author><name sortKey="Xie, Z" uniqKey="Xie Z">Z Xie</name></author><author><name sortKey="Uzer, G" uniqKey="Uzer G">G Uzer</name></author><author><name sortKey="Thompson, Wr" uniqKey="Thompson W">WR Thompson</name></author><author><name sortKey="Styner, M" uniqKey="Styner M">M Styner</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name></author><author><name sortKey="Rubin, J" uniqKey="Rubin J">J Rubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghosh, M" uniqKey="Ghosh M">M Ghosh</name></author><author><name sortKey="Song, X" uniqKey="Song X">X Song</name></author><author><name sortKey="Mouneimne, G" uniqKey="Mouneimne G">G Mouneimne</name></author><author><name sortKey="Sidani, M" uniqKey="Sidani M">M Sidani</name></author><author><name sortKey="Lawrence, Ds" uniqKey="Lawrence D">DS Lawrence</name></author><author><name sortKey="Condeelis, Js" uniqKey="Condeelis J">JS Condeelis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Hr" uniqKey="Kim H">HR Kim</name></author><author><name sortKey="Graceffa, P" uniqKey="Graceffa P">P Graceffa</name></author><author><name sortKey="Ferron, F" uniqKey="Ferron F">F Ferron</name></author><author><name sortKey="Gallant, C" uniqKey="Gallant C">C Gallant</name></author><author><name sortKey="Boczkowska, M" uniqKey="Boczkowska M">M Boczkowska</name></author><author><name sortKey="Dominguez, R" uniqKey="Dominguez R">R Dominguez</name></author><author><name sortKey="Morgan, Kg" uniqKey="Morgan K">KG Morgan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yun, Sp" uniqKey="Yun S">SP Yun</name></author><author><name sortKey="Ryu, Jm" uniqKey="Ryu J">JM Ryu</name></author><author><name sortKey="Jang, Mw" uniqKey="Jang M">MW Jang</name></author><author><name sortKey="Han, Hj" uniqKey="Han H">HJ Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyajima, D" uniqKey="Miyajima D">D Miyajima</name></author><author><name sortKey="Hayata, T" uniqKey="Hayata T">T Hayata</name></author><author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name></author><author><name sortKey="Hemmi, H" uniqKey="Hemmi H">H Hemmi</name></author><author><name sortKey="Nakamoto, T" uniqKey="Nakamoto T">T Nakamoto</name></author><author><name sortKey="Notomi, T" uniqKey="Notomi T">T Notomi</name></author><author><name sortKey="Amagasa, T" uniqKey="Amagasa T">T Amagasa</name></author><author><name sortKey="Bottcher, Rt" uniqKey="Bottcher R">RT Böttcher</name></author><author><name sortKey="Costell, M" uniqKey="Costell M">M Costell</name></author><author><name sortKey="F Ssler, R" uniqKey="F Ssler R">R Fässler</name></author><author><name sortKey="Ezura, Y" uniqKey="Ezura Y">Y Ezura</name></author><author><name sortKey="Noda, M" uniqKey="Noda M">M Noda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campos, Sb" uniqKey="Campos S">SB Campos</name></author><author><name sortKey="Ashworth, Sl" uniqKey="Ashworth S">SL Ashworth</name></author><author><name sortKey="Wean, S" uniqKey="Wean S">S Wean</name></author><author><name sortKey="Hosford, M" uniqKey="Hosford M">M Hosford</name></author><author><name sortKey="Sandoval, Rm" uniqKey="Sandoval R">RM Sandoval</name></author><author><name sortKey="Hallett, Ma" uniqKey="Hallett M">MA Hallett</name></author><author><name sortKey="Atkinson, Sj" uniqKey="Atkinson S">SJ Atkinson</name></author><author><name sortKey="Molitoris, Ba" uniqKey="Molitoris B">BA Molitoris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taiyab, A" uniqKey="Taiyab A">A Taiyab</name></author><author><name sortKey="Rao, Cm" uniqKey="Rao C">CM Rao</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Tomasello, Laura" sort="Tomasello, Laura" uniqKey="Tomasello L" first="Laura" last="Tomasello">Laura Tomasello</name></noRegion><name sortKey="Campisi, Giuseppina" sort="Campisi, Giuseppina" uniqKey="Campisi G" first="Giuseppina" last="Campisi">Giuseppina Campisi</name><name sortKey="Coppola, Antonina" sort="Coppola, Antonina" uniqKey="Coppola A" first="Antonina" last="Coppola">Antonina Coppola</name><name sortKey="Coppola, Antonina" sort="Coppola, Antonina" uniqKey="Coppola A" first="Antonina" last="Coppola">Antonina Coppola</name><name sortKey="Giordano, Carla" sort="Giordano, Carla" uniqKey="Giordano C" first="Carla" last="Giordano">Carla Giordano</name><name sortKey="Giordano, Carla" sort="Giordano, Carla" uniqKey="Giordano C" first="Carla" last="Giordano">Carla Giordano</name><name sortKey="Mauceri, Rodolfo" sort="Mauceri, Rodolfo" uniqKey="Mauceri R" first="Rodolfo" last="Mauceri">Rodolfo Mauceri</name><name sortKey="Pitrone, Maria" sort="Pitrone, Maria" uniqKey="Pitrone M" first="Maria" last="Pitrone">Maria Pitrone</name><name sortKey="Pitrone, Maria" sort="Pitrone, Maria" uniqKey="Pitrone M" first="Maria" last="Pitrone">Maria Pitrone</name><name sortKey="Pizzo, Giuseppe" sort="Pizzo, Giuseppe" uniqKey="Pizzo G" first="Giuseppe" last="Pizzo">Giuseppe Pizzo</name><name sortKey="Pizzolanti, Giuseppe" sort="Pizzolanti, Giuseppe" uniqKey="Pizzolanti G" first="Giuseppe" last="Pizzolanti">Giuseppe Pizzolanti</name><name sortKey="Pizzolanti, Giuseppe" sort="Pizzolanti, Giuseppe" uniqKey="Pizzolanti G" first="Giuseppe" last="Pizzolanti">Giuseppe Pizzolanti</name><name sortKey="Tomasello, Laura" sort="Tomasello, Laura" uniqKey="Tomasello L" first="Laura" last="Tomasello">Laura Tomasello</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000161 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000161 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5540218
|texte= Mesenchymal stem cells derived from inflamed dental pulpal and gingival tissue: a potential application for bone formation
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28764802" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |